fnctId=jbnuProfl,fnctNo=236
관리
학력
B.S., College of Advanced Science, Dankook university, Korea
M.S., Catholic university School of Medicine, Korea
Ph.D., Sungkyunkwan University School of Medicine, Korea
M.S., Catholic university School of Medicine, Korea
Ph.D., Sungkyunkwan University School of Medicine, Korea
경력
2019.09 ~ present Division of Life Sciences, Jeonbuk National University, Republic of Korea Assistant professor
2017.11 ~ 2019.08 Institute for Cancer Genetics, Columbia University, New York, NY Associate Research Scientist
2013.01 ~ 2017.10 Institute for Cancer Genetics, Columbia University, New York, NY Postdoctoral Research Scientist (Mentor: Dr. Antonio Iavarone and Dr. Anna Lasorella)
2011.08 ~ 2012.12 Samsung Biomedical Research Institute / Sungkyunkwan University School of Medicine, Korea Senior Researcher / PostDoc fellow (Mentor: Dr. Jee-Yin Ahn)
2017.11 ~ 2019.08 Institute for Cancer Genetics, Columbia University, New York, NY Associate Research Scientist
2013.01 ~ 2017.10 Institute for Cancer Genetics, Columbia University, New York, NY Postdoctoral Research Scientist (Mentor: Dr. Antonio Iavarone and Dr. Anna Lasorella)
2011.08 ~ 2012.12 Samsung Biomedical Research Institute / Sungkyunkwan University School of Medicine, Korea Senior Researcher / PostDoc fellow (Mentor: Dr. Jee-Yin Ahn)
발표논문
19) Lee S.B., Kim H.K., Oh H.K., Hong Y.K., and Joe Y.A. (2006) Mutation of Angiogenesis Inhibitor TK1-2 to Avoid Antigenicity In Vivo. J Appl Pharm. 14, 30-35. (Biomol Ther. 14, 30-35). IF(2018): 3.089
18) Xuan Nguyen T.L., Choi J.W., Lee S.B., Ye K., Woo S.D., Lee K.H., and Ahn J.Y. (2006) Akt phosphorylation is essential for nuclear translocation and retention in NGF-stimulated PC12 cells. Biochem Biophys Res Commun. 349(2), 789-798. IF(2018): 2.705, PMID: 16956580; DOI: 10.1016/j.bbrc.2006.08.120
17)Lee S.B., Oh H.K., Kim H.K., and Joe Y.A. (2006) e-x-p-r-e-s-s-i-o-n of the non-glycosylated kringle domain of tissue type plasminogen activator in Pichia and its anti-endothelial cell activity. Protein Expr Purif. 50(1), 1-8. IF(2018): 1.291, PMID: 16854593; DOI: 10.1016/j.pep.2006.06.002
16) Choi J.W.*, Lee S.B.*, Kim C.K., Lee K.H., Cho S.W., and Ahn J.Y. (2008) Lysine 263 residue of NPM/B23 is essential for regulating ATP binding and B23 stability. FEBS Lett. 582(7), 1073-1080. (* These authors contributed equally to this work). IF(2018): 2.675, PMID: 18319061; DOI: 10.1016/j.febslet.2008.02.059
15) Kim H.K., Oh D.S., Lee S.B., Ha J.M., and Joe Y.A. (2008) Antimigratory effect of TK1-2 is mediated in part by interfering with integrin alpha2beta1. Mol Cancer Ther. 7(7), 2133-2141. IF(2018): 4.856, PMID: 18645023; DOI: 10.1158/1535-7163.MCT-07-2405
14) Lee S.B., Xuan Nguyen T.L., Choi J.W., Lee K.H., Cho S.W., Liu Z., Ye K., Bae S.S., Ahn J.Y. (2008) Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival. Proc Natl Acad Sci USA. 105(43), 16584-16589. IF(2018): 9.580, PMID: 18931307; PMCID: PMC2569968; DOI: 10.1073/pnas.0807668105
13) Choi J.W., Lee S.B., Ahn J.Y., Lee K.H. (2008) Disruption of ATP binding destabilizes NPM/B23 and inhibits anti-apoptotic function. BMB Rep. 41(12), 840-845. IF(2018): 2.966, PMID: 19123973; DOI: 10.5483/bmbrep.2008.41.12.840
12) Nguyen N., Lee S.B., Lee Y.S., Lee K.H., Ahn J.Y. (2009) Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways. Neurochem Res. 34(5), 942-951. IF(2018): 2.782, PMID: 18846424; DOI: 10.1007/s11064-008-9848-9
11) Lee S.B., Kwon I.S., Park J., Lee K.H., Ahn Y., Lee C., Kim J., Choi S.Y., Cho S.W., Ahn J.Y. (2010) Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. J Biol Chem. 285(38), 29457-29468. IF(2018): 4.106, PMID: 20605787; PMCID: PMC2937978; DOI: 10.1074/jbc.M110.131367
10) Kim C.K.*, Nguyen T.L.*, Lee S.B.*, Park S.B., Lee K.H., Cho S.W., Ahn J.Y. (2011) Akt2 and nucleophosmin/B23 function as an oncogenic unit in human lung cancer cells. Exp Cell Res. 317(7), 966-975. (* These authors contributed equally to this work). IF(2018): 3.329, PMID: 21182834; DOI: 10.1016/j.yexcr.2010.12.013
9) Kim C.K., Lee S.B., Nguyen T.L., Lee K.H., Um S.H., Kim J., Ahn J.Y. (2012) Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization. Exp Cell Res. 318(2), 136-143. IF(2018): 3.329, PMID: 21930127; DOI: 10.1016/j.yexcr.2011.08.013
8) Park J.H.*, Lee S.B.*, Lee K.H., Ahn J.Y. (2012) Nuclear Akt promotes neurite outgrowth in the early stage of neuritogenesis. BMB Rep. 45(9), 521-525. (* These authors contributed equally to this work). IF(2018): 2.966, PMID: 23010173; DOI: 10.5483/bmbrep.2012.45.9.114
7) Lee S.B., Kim C.K., Lee K.H., Ahn J.Y. (2012) S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1/GAPDH death cascade. J Cell Biol. 199(1), 65-76. IF(2018): 8.891, PMID: 23027902; PMCID: PMC3461512; DOI: 10.1083/jcb.201205015
6) Ko H.R., Kim C.K., Lee S.B., Song J., Lee K.H., Kim K.K., Park K.W., Cho S.W., Ahn J.Y. (2014) P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP. Cell Death Dis. 5, e1131. IF(2018): 5.959, PMID: 24651434; PMCID: PMC3973206; DOI: 10.1038/cddis.2014.79
5) Lee S.B., Frattini V., Bansal M., Castano A.M., Sherman D., Hutchinson K., Bruce J.N., Califano A., Liu G., Cardozo T., Iavarone A., Lasorella A. (2016) An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 529(7585), 172-177 (Article). IF(2018): 43.070, PMID: 26735018; PMCID: PMC5384647; DOI: 10.1038/nature16475
4) Park J.H., Kim C.K., Lee S.B., Lee K.H., Cho S.W., Ahn J.Y. (2016) Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons. Sci Rep. 6(1), 21857. IF(2018): 4.011, PMID: 26899247; PMCID: PMC4761890; DOI: 10.1038/srep21857
3) Frattini V.*, Pagnotta S.M*., Tala, Fan J.J., Russo M.V., Lee S.B., Garofano L., Zhang J. Shi P., Lewis G., Sanson H., Frederick V., Castano A.M., Cerulo L., Rolland D.C.M., Mall R., Mokhtari K., Elenitoba-Johnson K.S.J., Sanson M., Huang X., Ceccarelli M., Lasorella A., Iavarone A. (2018) A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 553(7687), 222-227. (* These authors contributed equally to this work). Toker A and Liu H: F1000Prime Recommendation In F1000Prime, 01 Feb 2018; 10.3410/f.732450582.793541872 IF(2018): 43.070, PMID: 29323298; PMCID: PMC5771419; DOI: 10.1038/nature25171
2) Ko H.R., Jin E.J., Lee S.B., Kim C.K., Cho S.W., Yun T., Park K.W., Ahn J.Y. (2019) SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development. J Biol Chem. [Epub ahead of print]. IF(2018): 4.106, PMID: 31471318; DOI: 10.1074/jbc.RA119.009618
1) Wojnarowicz P.M., Lima E. Silva R., Ohnaka M., Lee S.B., Chin Y., Kulukian A., Chang S.H., Desai B., Garcia Escolano M., Shah R., Garcia-Cao M., Xu S., Kadam R., Goldgur Y., Miller M.A., Ouerfelli O., Yang G., Arakawa T., Albanese S.K., Garland W.A., Stoller G., Chaudhary J., Norton L., Soni R.K., Philip J., Hendrickson R.C., Iavarone A., Dannenberg A.J., Chodera J.D., Pavletich N., Lasorella A., Campochiaro P.A., Benezra R. (2019) A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 29(1), 62-75.e7 IF(2018): 7.815, PMID: 31577956; DOI: 10.1016/j.celrep.2019.08.073
18) Xuan Nguyen T.L., Choi J.W., Lee S.B., Ye K., Woo S.D., Lee K.H., and Ahn J.Y. (2006) Akt phosphorylation is essential for nuclear translocation and retention in NGF-stimulated PC12 cells. Biochem Biophys Res Commun. 349(2), 789-798. IF(2018): 2.705, PMID: 16956580; DOI: 10.1016/j.bbrc.2006.08.120
17)Lee S.B., Oh H.K., Kim H.K., and Joe Y.A. (2006) e-x-p-r-e-s-s-i-o-n of the non-glycosylated kringle domain of tissue type plasminogen activator in Pichia and its anti-endothelial cell activity. Protein Expr Purif. 50(1), 1-8. IF(2018): 1.291, PMID: 16854593; DOI: 10.1016/j.pep.2006.06.002
16) Choi J.W.*, Lee S.B.*, Kim C.K., Lee K.H., Cho S.W., and Ahn J.Y. (2008) Lysine 263 residue of NPM/B23 is essential for regulating ATP binding and B23 stability. FEBS Lett. 582(7), 1073-1080. (* These authors contributed equally to this work). IF(2018): 2.675, PMID: 18319061; DOI: 10.1016/j.febslet.2008.02.059
15) Kim H.K., Oh D.S., Lee S.B., Ha J.M., and Joe Y.A. (2008) Antimigratory effect of TK1-2 is mediated in part by interfering with integrin alpha2beta1. Mol Cancer Ther. 7(7), 2133-2141. IF(2018): 4.856, PMID: 18645023; DOI: 10.1158/1535-7163.MCT-07-2405
14) Lee S.B., Xuan Nguyen T.L., Choi J.W., Lee K.H., Cho S.W., Liu Z., Ye K., Bae S.S., Ahn J.Y. (2008) Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival. Proc Natl Acad Sci USA. 105(43), 16584-16589. IF(2018): 9.580, PMID: 18931307; PMCID: PMC2569968; DOI: 10.1073/pnas.0807668105
13) Choi J.W., Lee S.B., Ahn J.Y., Lee K.H. (2008) Disruption of ATP binding destabilizes NPM/B23 and inhibits anti-apoptotic function. BMB Rep. 41(12), 840-845. IF(2018): 2.966, PMID: 19123973; DOI: 10.5483/bmbrep.2008.41.12.840
12) Nguyen N., Lee S.B., Lee Y.S., Lee K.H., Ahn J.Y. (2009) Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways. Neurochem Res. 34(5), 942-951. IF(2018): 2.782, PMID: 18846424; DOI: 10.1007/s11064-008-9848-9
11) Lee S.B., Kwon I.S., Park J., Lee K.H., Ahn Y., Lee C., Kim J., Choi S.Y., Cho S.W., Ahn J.Y. (2010) Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. J Biol Chem. 285(38), 29457-29468. IF(2018): 4.106, PMID: 20605787; PMCID: PMC2937978; DOI: 10.1074/jbc.M110.131367
10) Kim C.K.*, Nguyen T.L.*, Lee S.B.*, Park S.B., Lee K.H., Cho S.W., Ahn J.Y. (2011) Akt2 and nucleophosmin/B23 function as an oncogenic unit in human lung cancer cells. Exp Cell Res. 317(7), 966-975. (* These authors contributed equally to this work). IF(2018): 3.329, PMID: 21182834; DOI: 10.1016/j.yexcr.2010.12.013
9) Kim C.K., Lee S.B., Nguyen T.L., Lee K.H., Um S.H., Kim J., Ahn J.Y. (2012) Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization. Exp Cell Res. 318(2), 136-143. IF(2018): 3.329, PMID: 21930127; DOI: 10.1016/j.yexcr.2011.08.013
8) Park J.H.*, Lee S.B.*, Lee K.H., Ahn J.Y. (2012) Nuclear Akt promotes neurite outgrowth in the early stage of neuritogenesis. BMB Rep. 45(9), 521-525. (* These authors contributed equally to this work). IF(2018): 2.966, PMID: 23010173; DOI: 10.5483/bmbrep.2012.45.9.114
7) Lee S.B., Kim C.K., Lee K.H., Ahn J.Y. (2012) S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1/GAPDH death cascade. J Cell Biol. 199(1), 65-76. IF(2018): 8.891, PMID: 23027902; PMCID: PMC3461512; DOI: 10.1083/jcb.201205015
6) Ko H.R., Kim C.K., Lee S.B., Song J., Lee K.H., Kim K.K., Park K.W., Cho S.W., Ahn J.Y. (2014) P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP. Cell Death Dis. 5, e1131. IF(2018): 5.959, PMID: 24651434; PMCID: PMC3973206; DOI: 10.1038/cddis.2014.79
5) Lee S.B., Frattini V., Bansal M., Castano A.M., Sherman D., Hutchinson K., Bruce J.N., Califano A., Liu G., Cardozo T., Iavarone A., Lasorella A. (2016) An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 529(7585), 172-177 (Article). IF(2018): 43.070, PMID: 26735018; PMCID: PMC5384647; DOI: 10.1038/nature16475
4) Park J.H., Kim C.K., Lee S.B., Lee K.H., Cho S.W., Ahn J.Y. (2016) Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons. Sci Rep. 6(1), 21857. IF(2018): 4.011, PMID: 26899247; PMCID: PMC4761890; DOI: 10.1038/srep21857
3) Frattini V.*, Pagnotta S.M*., Tala, Fan J.J., Russo M.V., Lee S.B., Garofano L., Zhang J. Shi P., Lewis G., Sanson H., Frederick V., Castano A.M., Cerulo L., Rolland D.C.M., Mall R., Mokhtari K., Elenitoba-Johnson K.S.J., Sanson M., Huang X., Ceccarelli M., Lasorella A., Iavarone A. (2018) A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 553(7687), 222-227. (* These authors contributed equally to this work). Toker A and Liu H: F1000Prime Recommendation In F1000Prime, 01 Feb 2018; 10.3410/f.732450582.793541872 IF(2018): 43.070, PMID: 29323298; PMCID: PMC5771419; DOI: 10.1038/nature25171
2) Ko H.R., Jin E.J., Lee S.B., Kim C.K., Cho S.W., Yun T., Park K.W., Ahn J.Y. (2019) SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development. J Biol Chem. [Epub ahead of print]. IF(2018): 4.106, PMID: 31471318; DOI: 10.1074/jbc.RA119.009618
1) Wojnarowicz P.M., Lima E. Silva R., Ohnaka M., Lee S.B., Chin Y., Kulukian A., Chang S.H., Desai B., Garcia Escolano M., Shah R., Garcia-Cao M., Xu S., Kadam R., Goldgur Y., Miller M.A., Ouerfelli O., Yang G., Arakawa T., Albanese S.K., Garland W.A., Stoller G., Chaudhary J., Norton L., Soni R.K., Philip J., Hendrickson R.C., Iavarone A., Dannenberg A.J., Chodera J.D., Pavletich N., Lasorella A., Campochiaro P.A., Benezra R. (2019) A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 29(1), 62-75.e7 IF(2018): 7.815, PMID: 31577956; DOI: 10.1016/j.celrep.2019.08.073